Thank you all for attending the 26th EGIR meeting in Lille, we will meet in 2019 in Lisbon as an EASD study group.

See enclosed the "professional minutes" of the last years EGIR meeting in Lille !

A special thanks to John Petrie and Jim Boyle from the University of Glasgow for writing the editorial published recently in Cardiovascular Endocrinology & Metabolism 2018, 7:73–74 .

Endorsed by :


European Group for the
Study of Insulin Resistance :
The EGIR Group

The EGIR group was formed several years agoby a group of investigators from different research backgrounds- epidemiology, endocrinology, basic science, public health -interested in insulin resistance.

The first combined activity of the EGIR Group was a data pooling project from euglycaemic hyperinsulinaemic clamp experiments performed in 21 centres across Europe.

EGIR Group maintains a unique database and produces more than 34 publications.

EGIR Group is managed by a Steering Committee and its scientific activities are managed by a separate Project Management Board.

EGIR Group holds annual meetings in different European cities, hosted by one of its members. Presentations are given by members of the group, and by invited speakers working in the field of insulin resistance and related subjects.

President of EGIR : Ele Ferrannini, CNR, Pisa, Italy
Secretary of EGIR : Lucrecia Mota, CNR, Pisa, Italy



Morning : Intestinal Diabetes
Chairs : Mina Mitrakou and Amar Abderrahmani
  • 08h45
    Welcome to Lille address
    François Pattou, University of Lille, France
  • 09h00
    Invited Speaker : Gilles Mithieux, INSERM U1213, Lyon, France
    Gut-brain glucose signaling in energy homeostasis
  • 09h30
    Invited Speaker : Alexander Miras, Imperial College London
    Effects of a RYGB with a long biliopancreatic limb on insulin sensitivity
  • 10h00
    Abstract Session 1
    Syntaxin phosphorylation as an insulin regulatory node of GLUT4 sorting in human muscle
    R. Livingstone, University of Glasgow, UK
    Mechanisms of the impaired incretin action in type 2 diabetes: a modelling study
    E. Grespan, CNR Institute of Neuroscience, Padova, Italy
    Evaluation of fructose metabolic fluxes in Human using stable isotopes
    K. Seyssel, University of Lausanne, Switzerland
  • 10h45
    Coffee Break
  • 11h00
    François Pattou, University of Lille, France
    Diabetes and glucose absorption
  • 11h30
    Abstract Session 2
    Six days of partial sleep restriction do not worsen the metabolic alterations induced by a mixed sugar-fat overfeeding
    J. Cros, University of Lausanne, Switzerland
    Insulin clearance is modulated by insulin sensitivity independently from hypersecretion and BMI
    R. Bizzotto, CNR Institute of Neuroscience, Padova, Italy
    Sglt1-/- mice on a glucose-diminished, fat-enriched diet display morphological and functional abnormalities of pancreatic islets
    D. Zdzieblo, University Hospital Wurzburg, Germany
  • 12h15
    Lunch on site
Afternoon : Metabolic Targets of NAFLD
Chairs : Philippe Lefebvre and John Jones
  • 14h00
    Invited Speaker : Bart Staels, Institute Pasteur de Lille, France
    Metabolic targets in the treatment of NAFLD
  • 14h30
    Invited Speaker : Catherine Postic, Institute Cochin, Paris, France
    The transcription factor ChREBP: From glucose sensing to Fatty Liver Disease
  • 15h00
    Abstract Session 3
    Severe hyperglycemia in 1000 intensive care unit patients: a higher mortality rate and a higher incidence of diabetes in a long-term follow-up study.
    A. Ben Hamou, University Hospital, Lille, France
    Transfer of 2H from Glucose to Specific Sites of Newly-Synthesized Triglyceride Fatty-Acids in Feeding Mice
    G. Debas Belew, Centre for Neurosciences and Cell Biology, University of Coimbra, Portugal
    Postprandial-Reduced Hepatic Insulin Extraction after Roux-en-Y Gastric Bypass using Minipig animal model
    M. Daoudi, European Genomics, Institute for Diabetes, Lille, France
  • 15h45
    Coffee Break
  • 16h00
    Invited Speaker : P. Froguel, European Genomics, Institute for Diabetes, Lille, France
    Liver growth factor PDGFA links human obesity to hepatic insulin resistance through epigenetic mechanism
  • 16h30
    Invited Speaker : Amalia Gastaldelli, CNR, Pisa, Italy
    Liver- muscle cross talk and amino acid metabolism in NAFLD
  • 17h00
    Keynote Lecture : Elé Ferrannini, CNR, Pisa, Italy
    Title of Presentation : to be announced
  • 17h30
    RISC Investigators Meeting and EGIR Annual General Meeting
  • 19h30
Morning : Islet Cell Demise in Diabetes
Chairs : Jean-Claude Henquin and John Petrie
  • 09h30
    Invited Speaker : Adrian Liston, VIB-KU Leuven, Belgium
    Beta cell fragility and the MANF pathway
  • 10h00
    Invited Speaker : Sven Gopel, AstraZeneca, Mölndal, Sweden
    SGLT2 blockers and Cardiac function : the 2 faces of glucagon
  • 10h30
    Coffee Break
  • 10h45
    Invited Speaker : Patrik Rorsman, University of Oxford, UK
    Insulin, somatostatin and glucagon in pancreatic islets : more than the sum of the parts ?
  • 11h15
    Invited Speaker : Jean-Sebastian Annicotte, CNRS, UMR 8199 Lille, France
    E2F1 and pancreatic beta cells: from function to dedifferentiation
  • 11h45
    Abstract Session 4
    Tobacco smoking results in reduced pancreatic islet mass
    M. Chetboun, European Genomics, Institute for Diabetes, Lille, France
    In vitro production of Human Pancreatic Islets from induced Pluripotent Stem Cells
    A. Vaissié, European Genomics, Institute for Diabetes, Lille, France
    The effect of insulin resistance in vivo on human islets
    J. Kerr Conte, European Genomics, Institute for Diabetes, Lille, France
    Not all T2D patients are insulin resistant
    H. Beck-Nielsen, Copenhagen, Denmark
  • 12h45
    Close of Meeting, François Pattou


07 June
François Pattou
University of Lille
Lille, France
Gilles Mithieux
Lyon, France
Alexander Miras
Imperial College London
London, United Kingdom
Bart Staels
Institute Pasteur
Lille, France
Catherine Postic
Institute Cochin
Paris, France
Philippe Froguel
CNRS, UMR 8199
Lille, France
Amalia Gastaldelli
Pisa, Italy
Elé Ferrannini
Pisa, Italy
08 June
Adrian Liston
Leuven, Belgium
Sven Göpel
Mölndal, Sweden
Patrik Rorsman
University of Oxford
Oxford, United Kingdom
Jean-Sebastian Annicotte
CNRS, UMR 8199
Lille, France


Mina Mitrakou
University of Athens
Athens, Greece
Amar Abderrahmani
CNRS, UMR 8199
Lille, France
Philippe Lefebvre
Lille, France
John Jones
Coimbra, Portugal
Jean-Claude Henquin
University of Louvain
Leuven, Belgium
John Petrie
University of Glasgow
Glasgow, United Kingdom




Lille, a warm and welcoming European metropolis

Close to major European capitals (35 min. from Brussels, 60 min. from Paris and 1h15 from London), in the heart of a region with more than 4 million people, Lille is a true European metropolis. Renowned for its warm and welcoming atmosphere, Lille receives several million visitors every year and offers a unique vision of Europe.

In recent years, Lille has been able to transform herself. From the status of Capital of Flanders, Lille has become a cultural and economic metropolis, recognised in Europe. Elected European Capital of Culture in 2004, it offers a large number of cultural activities and an exceptional urban life. The city has an attractive historical centre with a strong Flemish influence, three internationally renowned art museums and a rich nightlife.

With more than 100,000 students, Lille is one of the youngest cities in Europe. It offers many opportunities to meet, have fun and participate in cultural and sporting activities. With quick access to Paris, Brussels and London, Lille offers many opportunities to take part in major European events.


At the heart of a major business park in biology and health

Health care is an essential economic sector for Lille and its region. It is a veritable pole of economic development, made up of multinationals, SMEs and innovative start-ups. With constant growth and ever-increasing investments in Research & Development, this sector is experiencing sustained growth.

This progression is accompanied by Eurasanté, a regional development agency specialized in biology and health (development of international trade, establishment of foreign companies in France, support for start-ups, promotion of research, etc.).

A bridge to the healthcare industry

The Faculty's "Research" and "Training" divisions are located in the heart of Eurasanté Park, whose activities are dedicated to the biomedical sector. This privileged location brings our students and researchers closer to major players in the healthcare industry. The Faculty and the CHRU of Lille bring their academic and institutional expertise to their industrial partners.

Access Itinerary

All lectures will take place at the Faculty of Medicine, Research Centre (Pôle recherche) at Amphitheatre A (first floor, EAST wing).

To come at the Faculty of Medicine :

> from Lille Flandres station, take metro line 1 (direction CHRB-Calmette) and get off at CHR Oscar Lambret station, then 3 minutes on foot follow Claude Huriez hospital.

> from Lille Europe station, take metro line 2 (direction St. Philibert) change to Lille Flandres to take line 1 (direction CHRB-Calmette) and get off at CHR Oscar Lambret station, then 3 minutes on foot follow Claude Huriez hospital(you can also walk to the station Lille Flandres in 5 min).

> from the hotel Novotel Lille Centre, go to Rihour station, then take line 1 (direction CHRB-Calmette) and get off at CHR Oscar Lambret station, then 3 minutes on foot follow Claude Huriez hospital.


Novotel Lille Centre Grand Place Hotel

A 15-min walk from the train stations, the Novotel Lille Centre Grand Place hotel welcomes you to the heart of the French Flanders capital. Enjoy mussels and fries near the Grand Place, explore the bell tower and Vieux Lille.

Immerse yourself in the rich local customs before returning to your comfortable room. Four fully-equipped rooms are available for your business seminars. Relax in our fitness room, restaurant with terrace and video game room. Discover the Flemish art of living at Novotel.




Caroline Bonner ; François Pattou.

Organizing Committee / Lille :

Chiara Saponaro ; Valéry Gmyr ; Rofigua Hakem ; Julien Thévenet ; Corinne Courcol.

Scientific Secretary :

1, place de Verdun, Lille, FR

+33 320 62 76 62

Organizing Secretary :

1, place de Verdun, Lille, FR

+33 320 62 76 62